Children with Cholestatic Liver Disease: Pruritus Management
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Pruritus is a common complication of cholestatic liver disease that can significantly impair quality of life. Intractable pruritus is an indication for liver transplant regardless of PELD/MELD score. The pathophysiology of pruritus is complex. Several medications serve as standards for treatment and recent advances in quantification has allowed for rigorous and controlled study of new medications. In certain circumstances, liver transplant can be avoided or delayed with surgical biliary intervention.
Supported by educational grants from Albireo, Mirum and Travere.