Children with Cholestatic Liver Disease: Diagnostics
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Cholestatic Jaundice is a rare presentation of various hepatobiliary, metabolic, and genetic disorders. Cholestasis typically presents in the neonatal/infantile period but can also present late in older children or even adults. Early diagnosis and appropriate management of the underlying condition are of paramount importance for optimal prognosis. Diagnosis of cholestasis needs an array of investigations including blood tests, imaging, genetic testing, and invasive procedures like liver biopsy. Liver biopsy is one of the central crucial investigations done in evaluating children with cholestasis, however, can be associated with complications including bleeding. Understanding when to use a liver biopsy in children with cholestasis along with its limitations is extremely important to gain the maximum benefit out of an invasive procedure. Over the last decade, the growth in genetic techniques and the identification of new genes leading to cholestasis in children have evolved significantly and have led to the shrinking of the unidentified etiologies.
In this webinar, we will discuss when to perform a liver biopsy, its utility, and limitations. We will also discuss in-depth the rapidly evolving field of Genetic Cholestasis.
Supported by educational grants from Albireo, Mirum and Travere.
Saeed Mohammad, MD, MS (Moderator)
Associate Professor of Pediatrics Pediatric Gastroenterology, Hepatology, and Nutrition
Director, Pediatric Solid Organ Transplant Center, MCJCHV Vanderbilt University Medical Center
Samar Ibrahim, M.B.Ch.B, NASPGHAN-F (Moderator)
Consultant, Division of Pediatric Gastroenterology & Hepatology Associate Professor of Pediatrics and Physiology
Medical Director Pediatric Liver Transplant Program Mayo Clinic
Mohit Kehar, MD (Moderator)
Pediatric Gastroenterologist and Hepatologist Lead Pediatric NAFLD
Children’s Hospital of Eastern Ontario
Binita M. Kamath, MBBChir MRCP MTR
Division Head (interim) Fellowship Program Director Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children
Senior Associate Scientist, Research Institute Professor, University of Toronto
Saul J. Karpen MD PhD, FAASLD
Raymond F. Schinazi Distinguished Biomedical Chair Professor of Pediatrics
Division Chief, Pediatric Gastroenterology, Hepatology and Nutrition Emory University School of Medicine & Children's Healthcare of Atlanta
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