Cholestatic Jaundice is a rare presentation of various hepatobiliary, metabolic, and genetic disorders. Cholestasis typically presents in the neonatal/infantile period but can also present late in older children or even adults. Early diagnosis and appropriate management of the underlying condition are of paramount importance for optimal prognosis. Diagnosis of cholestasis needs an array of investigations including blood tests, imaging, genetic testing, and invasive procedures like liver biopsy. Liver biopsy is one of the central crucial investigations done in evaluating children with cholestasis, however, can be associated with complications including bleeding. Understanding when to use a liver biopsy in children with cholestasis along with its limitations is extremely important to gain the maximum benefit out of an invasive procedure. Over the last decade, the growth in genetic techniques and the identification of new genes leading to cholestasis in children have evolved significantly and have led to the shrinking of the unidentified etiologies.

In this webinar, we will discuss when to perform a liver biopsy, its utility, and limitations. We will also discuss in-depth the rapidly evolving field of Genetic Cholestasis.

Supported by educational grants from Albireo, Mirum and Travere.