Advances in Diagnosis and Treatment of Alagille Syndrome

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Alagille syndrome (ALGS) is a multi-system autosomal dominant disorder that often presents with neonatal cholestasis.  First described over 50 years ago by Daniel Alagille, this complex syndrome is caused by mutations in JAG1 or NOTCH2, encoding components of the Notch signaling pathway.  Ongoing research has led to a number of important recent advances in our understanding of ALGS.  Specifically, this webinar will focus on the state-of-the-art in genomic diagnostics (presented by Drs. Nancy Spinner and Melissa Gilbert), multi-center studies of disease outcome (presented by Dr. Binita Kamath) and new therapeutic options (presented by Dr. Saul Karpen).  The moderator, Dr. Kathleen Loomes, will summarize how our knowledge of the genetics and pathophysiology of ALGS might lead to new therapies.

Kathleen Loomes, MD (Moderator)

Co-Director of the Fred and Suzanne Biesecker Pediatric Liver Center

Children's Hospital of Philadelphia

Melissa Gilbert, PhD

Manager, Translational Research

Children's Hospital of Philadelphia Research Institute

Nancy Spinner, PhD, FACMG

Chief of the Division of Genomic Diagnostics

Children's Hospital of Philadelphia

Binita Kamath, MBBChir, MRCP, MTR

The Hospital for Sick Children

Saul Karpen, MD, PhD

Emory University School of Medicine

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LIVE Webinar Advances in Diagnosis and Treatment of Alagille Syndrome
02/08/2021 at 8:00 PM (EST)   |  90 minutes
02/08/2021 at 8:00 PM (EST)   |  90 minutes
Post-Test: Advances in Diagnosis and Treatment of Alagille Syndrome
7 Questions  |  Unlimited attempts  |  5/7 points to pass
7 Questions  |  Unlimited attempts  |  5/7 points to pass
Post-Webinar Evaluation: Advances in Diagnosis and Treatment of Alagille Syndrome
14 Questions
14 Questions Post-Webinar Evaluation: Advances in Diagnosis and Treatment of Alagille Syndrome
Certificate: Advances in Diagnosis and Treatment of Alagille Syndrome
1.00 credit  |  Certificate available
1.00 credit  |  Certificate available